Centre for Genomics Regulation (CRG)

This fellowship must be completed not later than November 2024

Centre for Genomics Regulation (CRG). The CRG is an international biomedical research institute of excellence whose mission is to discover and advance knowledge for the benefit of society, public health and economic prosperity. The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome to the cell to a whole organism and its interaction with the environment, offering an integrated view of genetic diseases.

Research proposals

The CRG will offer the successful candidates training and learning of specific skills and competencies in one or more of the research areas outlined below.

• Medical Genomics: dissecting human genome variation and its role in human rare and common diseases; applying genomics and disease models to define causal mechanisms and new therapies.
• Bioinformatics and Genomics: computational biology of RNA processing; comparative bioinformatics and genomics; gene function and evolution; genomic and epigenomic variation in disease; genomics and biodiversity.
• Cell and Developmental Biology: cell trafficking and secretion; microtubules function and cell division; cell and tissue dynamics; intra-cellular cell organization; oocyte biology and cellular dormancy.
• Gene Regulation Stem Cells and Cancer: mechanisms of gene expression and epigenetic regulation (from chromatin organization, alternative splicing, RNA modifications to mRNA translation); molecular basis of cellular decisions involved in tissue homeostasis and diseases, such as cancer; cell reprogramming and tissue regeneration.

• Systems Biology: dynamic gene regulatory networks; development and evolution (genomics, single cell approaches); systems neuroscience; combining systematic and quantitative data collection with computational models, to reach a deeper dynamic understanding of complex biological processes.
• Core Technologies Programme: offering services and training in advanced technologies such as light microscopy (including super-resolution microscopy), proteomics, genomics, tissue engineering, FACS, biomolecular screening and protein technologies.
• Synthetic biology.  Engineering of organism to introduce new properties for health and biotechnology